Mesalazine (5-aminosalicylic acid) induced chronic hepatitis
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چکیده
منابع مشابه
Mesalazine (5-aminosalicylic acid) induced chronic hepatitis.
BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...
متن کاملWhat dose of 5-aminosalicylic acid (mesalazine) in ulcerative colitis?
Sulphasalazine was developed in the 1930s, initially for use in patients with rheumatic polyarthritis. However, its modest eVects in arthritis were soon overshadowed by the striking benefits seen when the drug was given to patients with active colitis. Controlled clinical trials confirmed the early favourable impressions and established a role for sulphasalazine in the treatment of active disea...
متن کاملPENTASA Tablets and Sachets NAME OF THE MEDICINE Mesalazine (5-ASA) Synonyms: 5-aminosalicylic acid 5-amino 2-hydroxybenzoic acid
PHARMACOLOGY Pharmacotherapeutic group: Intestinal anti-inflammatory agents (A07 EC02). Actions: It has been established that mesalazine is the active component of sulfasalazine, which is used for the treatment of ulcerative colitis and Crohn’s disease. Based on clinical results, the therapeutic value of mesalazine after oral as well as rectal administration appears to be due to a local effect ...
متن کاملIn-vitro dissolution testing of 5-aminosalicylic acid release from pH dependent mesalazine formulations.
Figure 2 Experiment B: dissolution of Salofalk 1.5 g granules (batch no. 10F18833L) and Mezavant 1200 mg (batch no VB032) at sequential pH 1.0, 6.0, and 6.8 (n=6). We have read with interest the abstract presented at the last ECCO Congress by Tenjarla & Abinusawa1. While we agree with the authors' final statement that ‘consideration of the potential release profiles [of 5-ASA] may be a useful t...
متن کاملLeading article What dose of 5-aminosalicylic acid (mesalazine) in ulcerative colitis?
Sulphasalazine was developed in the 1930s, initially for use in patients with rheumatic polyarthritis. However, its modest eVects in arthritis were soon overshadowed by the striking benefits seen when the drug was given to patients with active colitis. Controlled clinical trials confirmed the early favourable impressions and established a role for sulphasalazine in the treatment of active disea...
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ژورنال
عنوان ژورنال: Gut
سال: 1999
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gut.44.6.886